We follow Cesare Borgia as he continues his conquest ousting Giovanni Sforza from Pesaro, Pandolfo Malatesta from Rimini and Astorre Manfredi from Faenza.

We are also introduced to one of his most important generals, Vitelozzo Vitelli and his vengeful hatred for the Republic of Florence who executed his brother.

Finally, France and Spain reach a secret pact for the division of the kingdom of Naples.