After the assassination of her husband Girolamo Riario, Caterina is in full control as regent for her son, Ottaviano Riario.

She has to navigate regional issues in Romagna, another assassination in Faenza and then the tricky balancing act during the descent of Charles VIII of France.

During all of this she managed to start a new passionate relationship with Giacomo Feo, which will also end in murder and in her thirst for vengeance, Caterina will lose sight of her role as a head of state.